Product Name	Boc Anhydride
CAS No	24424-99-5
Molecular Formula	C10H18O5
Molecular Weight	218.25
Appearance	Colorless solidified melt or fragments
Melting Point	20~25℃
puriy	99% min.
Packing	50kg/drum.
Storage	In cool, dry place
Lead Time	In stock

Notes:

Reagent for amino group protection as the t-butyl carbamate (t-butoxycarbonyl, Boc derivatives), in high yield under mild conditions, widely used in peptide chemistry^[1,2].
Benzyl carbamates(Cbz, Z) may be transformed into Boc in a one pot procedure catalysed by Pd/C^[3] .
Amides can be protected in the presence of a catalytic quantity of DMAP^[4,5]; the amide link of the product undergoes facile alkaline hydrolysis or methanolysis. The nitrogen function of indoles and pyrroles can also be protected under similar conditions^[6,7]. 1-Boc indoles may be synthesized from N-Boc 2-alkyl aniline ^[8].
The Boc group is readily cleaved with acid, most often Trifluoroacetic acid.
In the presence of 1 equivalent of DMAP in acetonitrile, arylamines are converted to isocyanates, generally in high yield; the dicarbonate here behaves as a convenient phosgene replacement^[9] . The same reagent system has also been applied nitroalkanes for the ambient temperature generation of nitrile oxides which were trapped in situ with dipolarophiles^[10] .
Feature on uses of this reagent in synthesis was reveiwed^[11].

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