产品名称	二碳酸二叔丁酯，Boc酸酐
英文名	Boc Anhydride; Di-tert-butyl dicarbonate; DiBoc; Di-tert-butyl pyrocarbonate; Dicarbonic acid bis(1,1-dimethylethyl)ester; Pyrocarbonic acid di-tert-butyl ester
CAS序号	24424-99-5
分子式	C10H18O5
分子量	218.25
外观	无色液体或半固体
熔点	20~25 ℃
纯度(GC)	不低于99%
包装	100ml/瓶；500ml/瓶；1000ml/瓶；50公斤/桶；180公斤/桶
贮存	阴凉干燥处保存；瓶装产品长期放置会产生较多气体，开启瓶盖时应注意防护！

小注：

Reagent for amino group protection as the t-butyl carbamate (t-butoxycarbonyl, Boc derivatives), in high yield under mild conditions, widely used in peptide chemistry [1,2] .
Benzyl carbamates(Cbz, Z) may be transformed into Boc in a one pot procedure catalysed by Pd/C [3] .
Amides can be protected in the presence of a catalytic quantity of DMAP [4,5] ; the amide link of the product undergoes facile alkaline hydrolysis or methanolysis. The nitrogen function of indoles and pyrroles can also be protected under similar conditions [6,7] . 1-Boc indoles may be synthesized from N-Boc 2-alkyl aniline [8] .
The Boc group is readily cleaved with acid, most often Trifluoroacetic acid.
In the presence of 1 equivalent of DMAP in acetonitrile, arylamines are converted to isocyanates, generally in high yield; the dicarbonate here behaves as a convenient phosgene replacement [9] . The same reagent system has also been applied nitroalkanes for the ambient temperature generation of nitrile oxides which were trapped in situ with dipolarophiles [10] .
Feature on uses of this reagent in synthesis was reveiwed [11] .

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