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共价化学公司产品应用实例(2010年度)
  1. A new electrochemiluminescence immunosensor based on Ru(bpy)3 2+-doped TiO2 nanoparticles labeling for ultrasensitive detection of human chorionic.  Li Mao, Ruo Yuan, Yaqin Chai, Ying Zhuo, Xia Yang.  Sensors and Actuators B, 2010, 149, 226-232.  [EDC.HCl]
  2. A novel non-radioactive assay for HIV-RT (RdDp) based on pyrosequencing for high-throughput drug screening.  Chang Zhang, Yang Wu, Yuna Sun, Chuan Hong, Kehui Xiang, Yu Guo, Mark Bartlam, Zhiyong Lou.  Protein Cell, 2010, 1(3):284-290.  [EDC.HCl] [Sulfo-NHS]
  3. A ratiometric fluorescent probe for cyanide: Convenient synthesis and the proposed mechanism.  Haibo Yu, Qin Zhao, Zhongxing Jiang, Jingui Qin, Zhen Li.  Sensors and Actuators B, 2010, 148, 110-116.  [EDC.HCl]
  4. A signal-on electrochemical probe-label-free aptasensor using gold–platinum alloy and stearic acid as enhancers.  Yali Yuan, Ruo Yuan, Yaqin Chai, Ying Zhuo, Lijuan Bai, Yuhong Liao(西南大学).  Biosensors and Bioelectronics, 2010, 26, 881-885.  [EDC.HCl] [NHS]  
  5. A validated stability-indicating HPLC method for the determination of PEGylated puerarin in aqueous solutions.  Xinyi Liu, Boyang Yu, Naijie Wang, Bei Zhang, Feng Du, Cheng He, Zuguang Ye(中国药科大学).  Journal of Chromatography B, 2010, 878, 2061-2066.  [EDC.HCl] [DMAP]
  6. Bioadhesion and oral absorption of enoxaparin nanocomplexes.  Wei Sun, Shirui Mao, Yanjun Wang, Varaporn B. Junyaprasert,Tingting Zhang, Lidong Na, Juan Wang(沈阳药科大学).  International Journal of Pharmaceutics, 2010, 386, 275-281.  [EDC.HCl] [NHS]
  7. Cholic Acid-Modified Dendritic Multimolecular Micelles and Enhancement of Anticancer Drug Therapeutic Efficacy.  Kun Zhang, Yongjian Wang, Ao Yu, Yue Zhang, Hao Tang, and X. X. Zhu(南开大学).  Bioconjugate Chem., 2010, 21(9):1596–1601.  [DCC] [NHS]
  8. Conjugation of Glucose Oxidase onto Mn-Doped ZnS Quantum Dots for Phosphorescent Sensing of Glucose in Biological Fluids.  Peng Wu , Yu He , He-Fang Wang and Xiu-Ping Yan(南开大学).  Anal. Chem., 2010, 82(4):1427-1433.  [EDC.HCl] [NHS]
  9. Construction of Polyethyleneimine-β-cyclodextrin/pDNA Multilayer Structure for Improved In Situ Gene Transfection.  Yan Hu, Kaiyong Cai, Zhong Luo and Ran Hu.  Advanced Engineering Materials, 2010, 12(1-2): B18–B25.   [CDI]
  10. Covalent attaching protein to graphene oxide via diimide-activated amidation.  Jianfeng Shen, Min Shi, Hongwei Ma, Bo Yan, Na Li, Yizhe Hu, Mingxin Ye(复旦大学).  Colloids and Surfaces B: Biointerfaces, 2010, 81, 434-438.   [EDC.HCl] [NHS]
  11. Detection of gastric carcinoma-associated antigen MG7-Ag in human sera using surface plasmon resonance sensor.  Xiangyi Fang, Jun Tie, Yonghong Xie, Quanjiang Li, Qingchuan Zhao, Daiming Fan(第四军医大学).  Cancer Epidemiology, 2010, 34, 648-651.  [EDC.HCl]
  12. Dual-cloud point extraction and tertiary amine labeling for selective and sensitive capillary electrophoresis-electrochemiluminescent detection of auxins.  Xue-Bo Yin, Jun-Min Guo, Wei Wei(南开大学).  Journal of Chromatography A,, 2010, 1217, 1399-1406.  [EDC.HCl] [NHS] [DCC] [HOOBt]
  13. Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals.  Xue Ying, He Wen, Wan-Liang Lu, Ju Dua, Jia Guo, Wei Tian, Ying Men, Yan Zhang, Ruo-Jing Li, Ting-Yuan Yang, De-Wei Shang, Jin-Ning Lou, Liang-Ren Zhang, Qiang Zhang(北京大学).  Journal of Controlled Release, 2010, 141, 183-192. [EDC.HCl]
  14. Effects of sodium houttuyfonate on expression of NF-kappaB and MCP-1 in membranous glomerulonephritis.  Pei Pan, Yu-Jie Wang, Lu Han, Xiang Liu, Meng Zhao, Yong-Fang Yuan.  Journal of Ethnopharmacology, 2010, 131, 203-209.  [EDC.HCl]
  15. Electrochemiluminescence of CdTe quantum dots as labels at nanoporous gold leaf electrodes for ultrasensitive DNA analysis.  Xiaofei Hu, Rongyue Wang, Yi Ding, Xiaoli Zhang, Wenrui Jin(山东大学).  Talanta, 2010, 80, 1737-1743.  [EDC.HCl]
  16. Enhanced efficacy of functionalized epirubicin liposomes in treating brain glioma-bearing rats.  Wei Tian, Xue Ying, Ju Dua, Jia Guo, Ying Men, Yan Zhang, Ruo-Jing Li(北京大学).  European Journal of Pharmaceutical Sciences, 2010, 41, 232-243. [EDC.HCl]
  17. Enhanced oral absorption of paclitaxel in N-deoxycholic acid-N, O-hydroxyethyl chitosan micellar system.  Hong Li, Meirong Huo, Jianping Zhou, Yindi Dai, Yaping Deng, Xiangjie Shi and Jumah Masoud.  Journal of Pharmaceutical Sciences, 2010, 99(11):4543-4553.  [EDC.HCl] [NHS]
  18. Fluorescence single-molecule counting assays for protein quantification using epi-fluorescence microscopy with quantum dots labeling.  Dafeng Jiang, Chunxia Liu, Lei Wang, Wei Jiang(山东大学).  Analytica Chimica Acta, 2010, 662, 170-176.  [EDC.HCl] [NHS]
  19. Gradient cross-linked biodegradable polyelectrolyte nanocapsules for intracellular protein drug delivery.  Shu, S., Zhang, X., Wu, Z., Wang, Z., & Li, C..  Biomaterials, 2010, 31(23):6039-6049.  [EDC.HCl] [NHS]
  20. Gradientcross-linkedbiodegradablepolyelectrolytenanocapsulesfor intracellularproteindrugdelivery.  Shujun Shu, XingeZhang, ZhongmingWu, ZhenWang, ChaoxingLi(南开大学).  Biomaterials, 2010, 31, 6039-6049.  [EDC.HCl] [NHS]
  21. Interchain Hydrogen-Bonding-Induced Association of Poly (acrylic acid)-graft-poly (ethylene oxide) in Water. Hao, J., Yuan, G., He, W., Cheng, H., Han, C. C., & Wu, C..  Macromolecules, 2010, 43(4), 2002-2008.  [EDC.HCl] [HOBt]
  22. High-Density Glycosylation of Polymer Membrane Surfaces by Click Chemistry for Carbohydrate–Protein Recognition.  Cang Wang, Jian Wu and Zhi-Kang Xu.  Macromolecular Rapid Communications, 2010, 31(12):1078–1082.    [EDC.HCl] [NHS]
  23. Immobilization of galactose ligands on thermoresponsive culture surface and its influence on cell adhesion/detachment.  Xiao-Ling He, Ping-Ping Nie, Yan-Kai Sun, Ying Wang, You-Yu Dong, Li Chen.  Journal of Colloid and Interface Science, 2010, 350, 471-479.  [EDC.HCl] [Sulfo-NHS]
  24. Laccase and alkali treatments of cellulose fibre: Surface lignin and its influences on fibre surface properties and interfacial behaviour of sisal fibre/phenolic resin composites.  Xinwen Peng, Linxin Zhong, Junli Ren, Runcang Sun(华南理工大学).  Composites Part A: Applied Science and Manufacturing, 2010, 41(12):1848–1856.  [HOBt]
  25. Lactoferrin-conjugated superparamagnetic iron oxide nanoparticles as a specific MRI contrast agent for detection of brain glioma in vivo.  Hui Xie1, Yanhong Zhu, Weili Jiang, Qing Zhou, Hai Yang, Ning Gu, Yu Zhang, Huibi Xu, Haibo Xu, Xiangliang Yang(华中科技大学).  Biomaterials, 2010, 1-8.  [EDC.HCl] [Sulfo-NHS]
  26. LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors.  Guopei Luo, Xianjun Yu, Chen Jin, Feng Yang, Deliang Fu, Jiang Long, Jin Xu, Changyou Zhan, Weiyue Lu.  International Journal of Pharmaceutics, 2010, 385, 150-156. [NHS]
  27. Novel Reduction-Responsive Cross-Linked Polyethylenimine Derivatives by Click Chemistry for Nonviral Gene Delivery.  Jia Liu, Xulin Jiang, Li Xu, Xianmiao Wang, Wim E. Hennink, and Renxi Zhuo(武汉大学).  Bioconjugate Chem., 2010, 21(10):1827–1835. [CDI] 
  28. One-step synthesis of pegylated cationic nanogels of poly(N,N0-dimethylaminoethylmethacrylate) in aqueous solution via self-stabilizing micelles using an amphiphilic macroRAFT agent. Lifeng Yan, Wei Tao(中国科技大学).  Polymer, 2010, 51, 2161-2167.  [DCC]
  29. Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: The effects of PEGylation degree and drug conjugation style.  Saijie Zhu, Minghuang Hong, Guotao Tang, Lili Qian, Jiayuan Lin, Yanyan Jiang, Yuanying Pei(复旦大学).  Biomaterials, 2010, 31, 1360-1371.  [EDC.HCl] [NHS]
  30. PEGylated PAMAM Dendrimer-Doxorubicin Conjugates: In Vitro Evaluation and In Vivo Tumor Accumulation.  Saijie Zhu, Minghuang Hong, Lihong Zhang, Guotao Tang, Yanyan Jiang, and Yuanying Pei(复旦大学).  Pharmaceutical Research, 2010, 27(1):161-174.  [EDC.HCl]
  31. Preparation and characterization of chitosan/galactosylated hyaluronic acid scaffolds for primary hepatocytes culture.  Jinyong Fan, Yi Shang, Yingjin Yuan and Jun Yang(天津大学).  Journal of Materials Science: Materials in Medicine, 2010, 21(1):319-327.  [EDC.HCl] [Sulfo-NHS]
  32. Preparation and formation mechanism of nanocomposites with fluorescent and magnetic properties.  H. Yan, J.C. Zhang, B.W. Yu, Y. Shen. Acta Materialia, 2010, 58, 726-733.  [EDC.HCl] [NHS]
  33. Preparation of folate-modified pullulan acetate nanoparticles for tumor-targeted drug delivery.  Zhang, H. Z., Li, X. M., Gao, F. P., Liu, L. R., Zhou, Z. M., & Zhang, Q. Q..  Drug delivery, 2010, 17(1):48-57.  [DCC]
  34. Preparation of phenylboronic acid functionalized cation-exchange monolithic columns for protein separation and refolding.  Xiangli Sun, Rui Liub, Xiwen He, Langxing Chen, Yukui Zhang(南开大学).  Talanta, 2010, 81, 856-864.  [Sulfo-NHS]
  35. Ru(bpy)3 2+-doped silica nanoparticles labeling for a sandwich-type electrochemiluminescence immunosensor.  Xia Yang, Ruo Yuan, Yaqin Chai, Ying Zhuo, Li Mao, Shirong Yuan(西南大学).  Biosensors and Bioelectronics, 2010, 25(7):1851-1855.  [EDC.HCl] [NHS]
  36. Self-Assembly of Gold Nanoparticles and Polystyrene: A Highly Versatile Approach to the Preparation of Colloidal Particles with Polystyrene Cores and Gold Nanoparticle Coronae.  Jia Tian, Jie Jin, Fan Zheng and Hanying Zhao(南开大学).  Langmuir, 2010, 26(11):8762–8768.   [EDC.HCl]
  37. Solid phase single-molecule counting of antibody binding to supported protein layers surface with low nonspecific adsorption.  Dafeng Jiang, Qianqian Zhang, Xibo Shen, Lei Wang, Wei Jiang(山东大学).  Talanta, 2010, 82, 1003-1009.  [EDC.HCl] [NHS]
  38. Surface Initiated Polymerization from Substrates of Low Initiator Density and Its Applications in Biosensors.  Hongwei Ma, Jian’an He, Xing Liu, Jianhong Gan, Gang Jin, and Jiahai Zhou(上海有机化学研究所).  ACS Appl. Mater. Interfaces, 2010, 2(11):3223–3230. [EDC.HCl] [Sulfo-NHS]
  39. Surface modification on polyurethanes by using bioactive carboxymethylated fungal glucan from Poria cocos.  Yifeng Wang, Wei Xu, Yanjun Chen(武汉理工大学).  Colloids and Surfaces B: Biointerfaces, 2010, 81, 629-633.   [EDC.HCl]
  40. Synthesis and drug release in vitro of porphyran carrying 5-Fluorouracil.  Zhongshan Zhang, Quanbin Zhang, Jing Wang, Xuelian Shi, Jingjing Zhang, Houfang Song(中国科学院海洋研究所).  Carbohydrate Polymers, 2010, 79, 628-632. [DMAP]
  41. Synthesis and Evaluation of Phenylalanine-Modified Hyperbranched Poly(amido amine)s as Promising Gene Carriers.  Xue Wang, Yongjie He, Jiayan Wu, Chao Gao and Yuhong Xu(上海交通大学).  Biomacromolecules, 2010, 11(1):245–251.  [DCC] [DMAP]
  42. Synthesis of hydrophilic and organophilic chemically modified graphene oxide sheets.  Jianfeng Shen, Min Shi, Hongwei Ma, Bo Yan, Na Li, Yizhe Hu, Mingxin Ye(复旦大学) .  Journal of Colloid and Interface Science, 2010, 351, 336-370. [EDC.HCl] [NHS]
  43. Synthesis of Lamivudine stearate and antiviral activity of stearic acid-g-chitosan oligosaccharide polymeric micelles delivery system.  Qian Li, Yong-Zhong Dub, Hong Yuanb, Xing-Guo Zhang, Jing Miao, Fu-De Cui, Fu-Qiang Hu(沈阳药科大学).  European Journal of Pharmaceutical Sciences, 2010, 41(3):498-507.  [DCC] [DMAP]

  44. Synthesis, self-assembly, and characterization of PEG-coated iron oxide nanoparticles as potential MRI contrast agent.  Chen Yue-Jian, Tao juan, Xiong Fei, Zhu Jia-Bi, Gu Ning, Zhang Yi-Hua, Ding Ye, and Ge Liang(中国药科大学).  Drug Development and Industrial Pharmacy, 2010, 36(10):1235-1244.  [EDC.HCl] [DMAP]

  45. Temperature-tuned DNA condensation and gene transfection by PEI-g-(PMEO2MA-b-PHEMA) copolymer-based nonviral vectors.  Jianhai Yang, Peng Zhang, Lei Tang, Peng Sun, Wenguang Liu, Pei Sun, Aijun Zuo, Dongchun Liang(天津大学).  Biomaterials, 2010, 31, 144-155. [CDI]

  46. The Use of Amino Acid Linkers in the Conjugation of Paclitaxel with Hyaluronic Acid as Drug Delivery System: Synthesis, Self-Assembled Property, Drug Release, and In Vitro Efficiency.  Dingcheng Xin, Ying Wang and Jiannan Xiang(湖南大学).  Pharmaceutical Research, 2010, 27(2):380-389. [EDC.HCl] [NHS]
  47. Thermoresponsive nanohydrogels cross-linked by gold nanoparticles.  Lian, X., Jin, J., Tian, J., & Zhao, H..  ACS applied materials & interfaces, 2010, 2(8): 2261-2268.     [EDC.HCl]
  48. Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain.  Zhao H. Wang, Zhan Y. Wang, Chang S. Sun, Chun Y. Wang, Tong Y. Jiang, Si L. Wang(沈阳药科大学).  Biomaterials, 2010, 31, 908-915.   [EDC.HCl]
  49. High solubility and photoluminescence quantum yield water-soluble polyfluorenes with dendronized amino acid side chains: synthesis, photophysical, and metal ion sensing properties. Qin, C., Wu, X., Tong, H., & Wang, L., Journal of Materials Chemistry, 2010, 20(37), 7957-7964.   [EDC.HCl] [HOBt]
  50. PEGylated PAMAM dendrimers as a potential drug delivery carrier: in vitro and in vivo comparative evaluation of covalently conjugated drug and noncovalent drug inclusion complex. Jiang, Y. Y., Tang, G. T., Zhang, L. H., Kong, S. Y., Zhu, S. J., & Pei, Y. Y., Journal of drug targeting, 2010, 18(5), 389-403.  [EDC.HCl]
  51. Intracellular Imaging with a Graphene‐Based Fluorescent Probe. Peng, C., Hu, W., Zhou, Y., Fan, C., & Huang, Q. , Small, 2010, 6(15), 1686-1692. [CDI]
  52. Synthesis and physicochemical characterization of biodegradable and pH‐responsive hydrogels based on polyphosphoester for protein delivery. He, J., Ni, P., Wang, S., Shao, H., Zhang, M., & Zhu, X., Journal of Polymer Science Part A: Polymer Chemistry, 2010, 48(9), 1919-1930. [DCC] [DMAP]
  53. 苯并二氮杂唑酮酸的合成及其在肽模拟中的应用.  袁建海, 杨潇骁, 林浩, & 王德心, 有机化学, 2010, 30(07), 1010-1016.  [HBTU]
  54. 菌种 L3 深层发酵产漆酶及其对废水脱色的研究. 刘家扬, 蔡宇杰, 廖祥儒, 王欣, 张峰, & 张大兵.  工业水处理, 2010, 30(2), 27-30. [HOBt]
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